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Introduction

Testicular cancer is a highly curable malignancy that arises from the testicles (male reproductive glands located in the scrotum). It is most common in young men (15–40 years old) and accounts for 1–2% of all male cancers.

Most cases are germ cell tumors (GCTs), which are further classified into seminomas and non-seminomas. Testicular cancer is one of the most curable solid tumors, even in advanced stages, with a 5-year survival rate >95% when treated appropriately.

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Types of Testicular Cancer

1. Germ Cell Tumors (90–95% of cases)

2. Non-Germ Cell Tumors (5–10%)

Signs and Symptoms

Risk Factors

  • Cryptorchidism (Undescended testis – 5–10× increased risk).
  • Family history of testicular cancer.
  • Personal history (contralateral testicular cancer increases risk).
  • Klinefelter syndrome (XXY genetic disorder).
  • Testicular atrophy or trauma.
  • HIV infection.

Signs and Symptoms

  • Painless lump or swelling in the testicle (most common).
  • Heaviness or discomfort in the scrotum.
  • Pain in the testicle or lower abdomen (30% of cases).
  • Back pain (suggests lymph node involvement).
  • Gynecomastia (breast enlargement in hormone-secreting tumors).

Diagnosis

1. Clinical Examination
2. Tumor Markers (Blood Tests)
3. Imaging for Staging

Treatment Options

1. Surgery (Radical Inguinal Orchiectomy) – First-line treatment
2. Chemotherapy
3. Radiation Therapy
4. Retroperitoneal Lymph Node Dissection (RPLND)

Prognosis and Follow-Up

  • Overall 5-year survival: >95%.
  • Seminoma (Stage I) – Cure rate >99%.
  • Non-seminoma (Stage III) – Cure rate ~70–80% with aggressive treatment.

Follow-up (After Treatment)

  • Tumor marker levels (AFP, β-hCG) checked regularly.
  • CT scans every 3–6 months for the first 2 years.
  • Regular testicular self-exams for recurrence in the contralateral testis.

Frequently Asked Questions (FAQs)


A: Yes, it is one of the most curable cancers, even in advanced stages, with a >95% survival rate.
A: Yes, it can spread to the lymph nodes, lungs, liver, and brain. However, chemotherapy is highly effective.
A: Usually not. The remaining testicle compensates, but sperm banking is recommended before treatment.
A: A painless lump, swelling, or heaviness in the testicle is the most common early sign.
A: It is a personal choice. Many men opt for a testicular implant for cosmetic reasons.

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